Single-Cell Spatiotemporal Atlas of Mouse PFC

This project generated a spatiotemporal single-cell atlas of the mouse prefrontal cortex (PFC) during early postnatal development, revealing dynamic molecular and cellular changes, particularly in intratelencephalic (IT) neurons. Our analyses identified time-specific gene expression programs, neuron–glia interactions, and signaling pathways underlying IT neuron maturation, providing a valuable resource for understanding PFC development and related neurological disorders.

I contributed by performing single-cell RNA-seq analyses, supporting the construction of the spatiotemporal atlas and the investigation of neural circuit development.